The resettlement of the Ohlone and other Native Americans by the Spanish at Mission Santa Clara de Asís forever ruptured local cultural life-ways. In 1770, approximately 10,000 Ohlone lived along California’s central coast (Skowronek 2002: 4). By the end of the Third mission site – only 42 years later – 1,000 Ohlone remained (Cortez 2002: 61). The Third mission site was the epicenter of this demographic and cultural disruption, as it was the place where Christianization and assimilation of the native inhabitants took place.
On November 19th, 1781, the cornerstone of the third mission was laid near what is now the northeast corner of SCU’s campus (Skowronek & Wizorek 1997: 57). Over the next 35 years, the third mission would be completed, as well as surrounding structures. However, its position near several small streams undermined the building’s foundations; and in 1812 and 1818, earthquakes damaged the third mission site, and it too was abandoned. This mission site at once represents the disruption of a native group of people and the destructive forces of natural disasters.
Additional Information:

Fig. 3: Table that explains the fates or current status of the Mission Santa Clara locations (Skowronek & Wizorek 1997: 55)
History of the Mission Santa Clara de Asís: this SCU page provides more detailed information on the history of the mission.
For an educational and illustrated book on Ohlone and post-Colonial life on the Guadalupe River, check out:
Allen R., & M. Hylkema. (2002). Life along the Guadalupe River: an archaeological and historical journey. San Jose, CA: Friends of Guadalupe River Park and Gardens.
For more information on Ohlone life at the mission, check out:
Skowronek, R. K. (1998). “Sifting the Evidence: Perceptions of life at the Ohlone (Costanoan) missions of Alta California.” Ethnohistory 45(4):45-78.